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EDIT: Patch #1 is now released!You can view the patch notes here. This list has been updated to remove all bugs/oddities fixed in this update. If I've missed any, please let me know.
Patch #1's notes mention that Mom's Shovel now counts towards the Mom transformation. However, this is still untrue.
You can save and continue twice to get your Holy Mantle shield back, meaning that this exploit still exists despite an attempted patch
Dark Red The Thing Champions, the ones that were disabled in the last patch because of buggy behavior, may still be able to spawn in Greedier mode.
Some people are reporting major audio-balancing issues ever since the patch, with sound effects nearly silent/muffled with music being loud/fine. This could be hard to troubleshoot without hardware info from people experiencing the bug.
'Multichannel audio still seems to be bugged on Windows. Music comes from the front left and front right channels and sound effects come from the rear right and rear left channels. This happens in 5.1, 7.1, and Dolby Atmos for Home Theater settings via HDMI to a home theater receiver.' - /u/jedcred
EDIT: /u/jedcred has also reported that he was able to fix this issue by replacing the OpenAL version Isaac ships with with one of the latest versions. This appears to fix the issue and plays back the audio in stereo mode only. While it's unknown if this causes any other issues, it's what appears to have worked for this one user.
In Onan's Streak, taking damage from a tear missing will cancel the 'holding trophy' animation, removing the trophy and softlocking the challenge.
Mama Mega causes unavoidable damage when entering rooms that have TNT barrels/mushrooms near the door.
After exhausting most items, the D4 can grant items that haven't been unlocked yet.
The D1, when copying chest, does not copy the chest contents, unlike other duplication items like Jera.
D1 can also duplicate opened chests into unopened copies, unlike Jera.
When Squirts or Dank Squirts are both Feared and Confused at the same time, their physics bug out completely and snap across to different spots in the room.
YO LISTEN! can still point to unreachable crawlspace locations, on pits, poop, and empty tiles.
This also apparently occurs with Dog Tooth's barking sound, reportedly heard in rooms with metal blocks.
Champion versions of the Gush enemy cause them to inflict half a heart of contact damage, despite the Booster 5 changelog mentioning fixing this with most enemies.
Permanently charmed Gush enemies does not spawn any slowing creep, defeating the purpose of having a charmed version of one.
White Champion Pestilence's white creep does not slow the player down.
Incubus (And thus Lilith) and Fate's Reward completely ignore the shot speed stat.
When a boss that splits into other entities at low health is killed while frozen with Pause and another status-afflicted source (Petrified/Midas Touch) at the same time, the boss will be permanently frozen and become immune to any damage, softlocking the battle.
When Ipecac's tear size is big enough (Through various tear-size items or damage ups), the tear will fail to harm most enemies, as the edge of the tear impacts with the enemy but the explosion spawns at the center, missing enemies entirely. Ipecac explosions could scale with the tear's size to correct this, big or small.
Coin drops from Yellow Champions spawn multiple coins on top of the same location, so what looks like one penny is actually multiple
To add, the amount of coins/coin type dropped by these Champions may be unseeded.
With Dim/Vibrant Bulb and Schoolbag, stats aren't updated when items are swapped, allowing for the stat-ups to be permanent as long as long as the current item's charge isn't updated or stats are updated through other means.
The Equality trinket misbehaves with shops, spawning free copies of pickups in shops instead of altering the current shop pickup state like how Humbling Bundle does. This is likely not intentional.
Equality can duplicate the pickup you have just picked up to activate it, because it changes the state of the pickup from 'Despawning from collection' to 'Spawning as a double version of the pickuptype'.
Immaculate Conception's counter does not go up if you're granted hearts directly via an item, only through pickups.
The poison clouds from Contagion can harm your permanently charmed enemies.
In the Backasswards challenge, the first room of the floor is made visible on the map through the Mom's Dresser icon, unintentionally giving the player a sort of compass for the challenge.
Accessing the Error room at Basement 1 of the Backasswards challenge will softlock the run.
Greed mode can become softlocked from teleporting to a secret room, by an Eden that starts with Undefined or as any character with Dead Sea Scrolls.
In Backasswards, bosses can be encountered twice in a row without remembering which ones you've already fought (For example, you fight a boss at Caves 2, but you fight it again at Caves 1)
Sacrificial Altar can be used infinitely if consumed by the Void.
Lvl 2 Bumbo walks through objects as if he has flight
Killing the legs of Daddy Long Legs/Triachnid during the 'scatter stomp' will have the legs play the death animation of the whole boss, despite the boss not actually being dead. This causes two heads of the boss to appear for about a second.
In the Ultra Hard challenge, trapdoors to both Sheol and the Cathedral can spawn, despite only given the Negative.
If Shovel Piece 2 is picked up without having Piece 1, the shovel cannot be formed even after picking up Piece 1 again. This can be done by swapping active items within the Boss Rush room.
'Usually when a Boss Challenge Room is adjacent to a Secret Room, you can bomb into it. However, if you encounter Greed instead, the side which you'd bomb yourself through will have the barred door sprite and won't unlock/be bombable even after the fight ends.' and 'If you bomb yourself into a Boss Challenge Room and leave without starting it, the bombed entrance will seal again. (not sure if intentional)' - /u/Sebastianey
Champion bosses don't drop the hearts they're supposed to if there are multiple bosses in the same room, unless they are killed last. This leads to issues such as Champion drops in Boss Rush, or Mask of Infamy Champions never dropping hearts since only the Heart is considered a Champion.
Or, spawning both Angels at the same time in one Angel Room (from some layouts having 2 statues) only dropping 1 key piece after the battle.
'If you have the broken remote equipped and you use Moms Shovel in the room where you unlock the forgotten, you teleport out, don't unlock the forgotten and then can not unlock the forgotten on that run. Please do not ask me how I know this.' - /u/talking-box
Sacrificial Altar will be consumed if used with 7 Seals, but will not award a Devil Deal item or remove 7 Seals.
Angry Fly cannot be sacrificed with the altar despite being a living familiar.
Sulfuric Acid does not break rocks/open secret rooms when you also have spectral tears, rendering the item mostly ineffective.
Widow appears to have some troubles spawning Sacks with her white creep attack often. Many times the attack will fail to spawn the Sack, and sometimes she'll attempt the spawn several times in a row and fail each time. At first I thought she was on a cooldown before she can spawn another, and that might be the case, but there can be long periods of time where she keeps failing to spawn. Hard to judge if this is intended behavior or not.
Eden can randomize the passive Broken Shovel piece, which shouldn't be possible for them (like how they can't randomize into the key pieces)
When you lose Schoolbag via rerolling or other methods and have two active items, the game doesn't drop the second item to the floor and still acts as if you have Schoolbag.
Same behavior also occurs with Mom's Purse/Starter Deck when those items are lost via D4/Clicker/other items or methods, the effect isn't removed.
When you use a Sacrifice Room until you get two 'You've been blessed' messages, the Found HUD will incorrectly state that you have a 100% Angel chance, when the actual percentage is closer to 65%.
Using Pause with permanently charmed enemies, if you exit the room while still paused, your allies will be frozen until you use Pause again.
For the Sin Collector achievement, intended to be unlocked at full bestiary completion, is bugged in that it incorrectly counts entities that aren't in the bestiary. Now with plenty of new rooms with the Broken Maw, it should be a bit more reasonable to 100% the bestiary if fixed.
The 'How to play' floor doodles in Greed mode disappear if you reenter the main room from the Silver Treasure Room (but reappear if you exit from any other room)
Hush's Blue Gapers are only registered/counted in the bestiary if you encounter them in one of the few rare rooms they're in, making them harder to get an entry for than they should be.
Accessing Devil/Angel rooms through different methods generates a completely different Devil/Angel layout even when using the same seed. So accessing a Devil Room through the boss, Joker, Red Chest, etc. all leads to different layouts generating, which can cause 'unseeded' issues with races/Daily Runs.
Rerolls done by the D20 (and the Dice Rooms?) are unseeded
Broken Stopwatch's time effect (notably speed up) can be removed by exiting and continuing a run.
The last wave of Boss Rush only gives 1 item charge instead of the usual 2 for other waves.
Dark Princes Crown + Strength: With all soul hearts and using Strength for the temporary heart, which triggers the crown, the crown continues to glow in later rooms despite being inactive
When the 404 trinket rolls the Duct Tape effect, your familiars snap to the opposite side of the room.
Ultra Pride's baby has a roughly 1/50 chance to be replaced by an Angel Baby.
If the primary player is playing with a controller and a second player joins with the keyboard, they are immediately sent into the game with a random baby instead of being able to select a baby.
Longstanding bug: Wrath of the Lamb alt floors unlock when you kill every available boss on the vanilla floors. However, for The Basement/Cellar, Gemini counts for two bosses, and The Cellar unlock counter will only count whichever of the two is killed last. Meaning, the larger twin (Contusion) will only count when the baby is killed first.
There is some sort of failsafe in the game to prevent getting stuck in certain rooms by waiting long enough. While it isn't completely understood, this failsafe does not seem like it has the ability to open boss doors, still resulting in a softlock, as well as some reports that there's rooms you can softlock in with pressure plates (Notably ones surrounded by Red Poop, which you can't destroy without bombs in blindfold challenge runs) that don't open from this failsafe.
Ludovico + Fruit Cake: The Ludo tear eventually splits apart into tons of other tears, and all those tear eventually split as well, repeating infinitely while also creating a storm of stuck Trisagion beams.
Ludo + Fruit Cake + Monstro's Lung: Causes the added tears to permanently take on the first Fruit Cake effect when entering a room.
Tractor Beam + Pop! + Continuum: Very buggy interaction, as the tears never fall as they're too busy bouncing off each other trapped in the tractor beam. This can cause the stream to be very visually buggy, especially with hitboxes, and it's assumed this eventually reaches the tear cap.
Dr. Fetus + Scatter Bombs + Fire Mind (Not Hot Bombs): Causes the fires created by scatter bombs to harm the player.
Tech X does not synergize with Azazel's Brimstone, which is inconsistent with other Brimstone synergies with him.
Guppy + Mom's Knife: Does not generate flies, while Knife + Mulligan spawns flies just fine
Ludovico makes Sprinkler entirely ineffective, as the Sprinkler no longer fires any tears.
Proptosis + Soy Milk + Ipecac: It's impossible to fire without hurting yourself, as your Ipecac bomb explodes right in front of your face. This is caused by the awful, awful range given by Soy Milk + Proptosis.
Brimstone + Ipecac + Ghost Pepper: If an Ipecac shot launches at the same time as a Ghost Pepper fire while charging, the Ipecac will collide with the fire and blow up in the player's face, resulting in unavoidable damage.
The current Brim + Ipecac combo is also odd, as the two now fire separately while prior to AB+ Ipecac just made Brimstone green + deal poison. It's unclear if this is intentional or a bug.
Ludo + Ghost Pepper: The ludo tear is oddly destroyed by touching the Ghost Pepper fires, respawning the tear at the player's position.
Monstro's Lung + Chocolate Milk w/ Incubus: Fired shots from Incubus will deal 1/10th the normal damage, the lowest damage Chocolate Milk shots. This can kill a run with Lilith unintentionally.
Breath of Life double-charged with The Battery: The item still works but the charge gauge doesn't visually update, making it a bit harder to pinpoint when exactly it will be fully charged again or when to release the use button.
When you have Technology 2 + Lead Pencil, you can no longer fire tears.
Ludo + Brimstone + Dr. Fetus is entirely broken, with a static, non-animated Brimstone ring you can't control fixed to your character.
Same bug occurs with Ludo + Technology/Mom's Knife + Dr. Fetus
The interaction between Ludo + Bookworm transformation is very visually buggy.
Ludo + Explosivo: Synergy is broken. The Ludo tear sticks to the enemy, rapidly grows, then 'splashes' with no explosion, dealing almost no damage. Attached video: https://youtu.be/c_AyTj-AG9I
Ludovico + Sinus Infection: Similar occurs as above, where the tear sticks to the opponent for hardly 2 ticks then respawns at the player.
Godhead and Eye of Belial: The aura around the tears won’t deal damage after the tear hits an enemy.
BFFS! does not increase the damage of fly turrets spawned with Brown Nugget, despite increasing the size of the flies.
Bomber Boy halves the damage of bomb-based familiars (Bob's Brain/BBF) without giving them the cross explosion, directly nerfing them if you have Bomber Boy.
Void + White Pony doesn't create light beams
Lump of Coal + Maw of the Void/Athame: Halves the damage of the void ring.
Metronome has a few buggy reactions with various item effects, some of which I have taken from the Wiki:
Car Battery messes with Metronome, making Isaac show one item effect above his head, when actually that effect is replaced by a second, unknown item effect.
Item effects cannot be stacked if used several times in one room, which also leads to issues such as with the Car Battery.
Items do not spawn consumables that they would when picked up normally.
Items that change Isaac's size do not change Isaac's size (and should revert them afterwards)
HP Ups are not reverted, seems slightly unintentional and should instead function sorta like the Strength card. You can easily max out health by simply using Metronome enough.
The item safeguards you by blacklisting certain items such as Glowing Hour Glass and Plan C so it doesn't screw you up. However, D4, D100, D Infinity, and Clicker can all still be randomized, resulting in very undesired results.
List of items found to not function properly when rolled with Metronome: Experimental Treatment, The Candle (And presumably other actives where you raise something above your head), extra-life granting items (Judas' Shadow, Dead Cat, etc), Breath of Life, all items that reveal parts of the minimap, How to Jump
This post had reached the Reddit character limit, so you can find The Forgotten section on Pastebin here: https://pastebin.com/gZxqHtgY
The scale factor of the Angel and Devil Room door animations are entirely off, resulting in some stray/buggy pixels. This mod corrects this.
With a charging item, if you pick up another item that removes the charge (Such as Mom's Knife + Ludo) while charging, the charging bar animation will become stuck and persist through rooms/floors
Room wall graphics have been visually buggy ever since Rebirth in rooms other than 1x1 graphics overlapping on each other, which occurs on every floor but is most noticeable in floors such as the chest. Supposedly there have been mods in the past that have fixed this, so it's definitely fixable.
The Chest also has extremely noticeable seams in the flooring in nearly every room
The creator of the 'More Dirt Sprites' mod has chimed in to say that he has since updated his mod for support for several other dirt types in the game. Specifically: Depths, Necropolis Blue Womb, and Sheol. Considering how well the new colors match the given floors, it would be nice to have them added for more consistency.
The Frail does not properly update its dirt color to match the current floor color when it turns into its skeletal form.
Permanently charmed enemies do not update their dirt color when changing floors
Suggested fix for a lot of dirt sprite issues: Make dirt sprites dependent on backdrop instead of floor.
All Vis enemies are missing their butts in their sprite when firing upwards.
When dying to an enemy of an unknown source, the game defaults to using The Matriarch's death doodle. A known attack that triggers this is the bullets fired from The Lamb's body.
Dying from contact damage from a Turdling uses the death doodle of Black Maw, not Turdling's.
Crown of Light mistakenly glows as if it's active when it's not when the player has empty red hearts but some soul hearts.
When using a controller, the 'Press Tab for-' text does not change its appropriate button graphic (In this case, Tab) for toggling mods or viewing modded challenges, while meanwhile this functionality already exists to change the text for 'Press [button] for Daily Challenge'
Viewing Daddy Long Legs or Triachnid in the bestiary, backing out and scrolling to the bottom of the Challenge list creates a visual bug involving those bosses' legs.
L-shaped rooms and closet/hallway rooms in the Dark Room lack the 'crumbling platform' sprite at the bottom of the floor.
Dark Prince's Crown lacks an apostrophe in its in-game name, when the item has one when named in the Steam Achievement and secret unlock banner.
Baby and Angelic Baby enemies can fire without playing their firing animation/sound if the fire right after they come in from a teleport.
Hosts, Mobile Hosts, and their flesh versions can sometimes fire bullets without animation/sound when coming out of the Fear status effect.
Whereas the Blank Candle (and by extension Dagaz) was updated in the patch to fade away Curse of Darkness, the Night Light item still has an instant Curse of Darkness removal.
Incubus has a custom Brimstone shooting sprite, but it goes unused.
The 'room transition fade' effect doesn't work properly when two L-shaped rooms are nested into each other, though a rare occurrence.
On the main menu, selecting Hard mode darkens the UI. However, Greed and Greedier both keep the darkened screen, when only Greedier should logically have it (As it's the Greed hard mode)
The 'light ring' from Holy Mantle does not appear when you have flight, which can make it harder to judge when you get hit (Especially as The Lost).
There's an inconsistency in the designs of the co-op baby secret unlock banners. All of the co-op babies unlocked from hardmode Mom's Heart read 'You unlocked '(name)'. However, all the co-op baby unlocks added in further DLCs read '(name)' has appeared in the basement,' incorrectly presenting them as if the babies are items to find rather than co-op buddies. This can cause some confusion when you wouldn't be able to tell if 'Fart Baby' is a co-op baby or not at first glance on unlock.
EDIT: User /u/ZapperZakuTwo has helped contribute by fixing every single co-op baby unlock sprite that has this confusing inconsistency. You can download the zip file I compiled of every one here on Dropbox, each one already correctly named.
Also contributed are fixed unlock banners for Sacrificial Dagger, which is incorrectly named 'Sacrificial Knife' in the current banner, and optionally Blood Rights, which currently uses a bloody pentagram for its art instead of what it actually is, a razor (which is very likely intentional, but just in case).
The headlight for the Spelunker Hat is cut off when facing upwards.
Fireflies in L-shaped rooms are attracted to and all clump into a big ball in the center of the room.
Something similar happens when tons of maggots are clumped in a corner when spawned and trapped against a wall and pit.
The light ring graphic for Dad's Ring can be overridden by various items like Holy Mantle, making it hard to judge where the ring actually is.
Blighted Ovum's boss portrait implies his body has skin, when in actuality his body is red and skinless.
Headless Horseman's portrait also has an inaccurate color for his horse and is two-eyed instead of one-eyed. This simple edit by /u/ZapperZakuTwo corrects this.
There's a 1-pixel width difference between the spiked mimic chest sprites, leading to a noticeable change on the width when the spikes pop out in-game.
In The Void, rooms with the Dark Room room graphic lack the purple cloud background effect the floor has, while all other room designs in The Void have their layers and graphics intact. Hard to tell if it's an oversight or intentional.
Mongo Baby has a left-facing sprite in its spritesheet, but is never used, and instead the right-firing sprite is mirrored for it instead - /u/AdministrativeCreme
This is also true for Rotten Baby (+ Lil Delirium form of it). And stage 2 of Ball of Bandages. All 3 of these familiars have custom left-facing sprites that aren't used. The left-facing sprite of stage 2 Ball of Bandages does not blink when shooting, which should be corrected if fixed.
The Money = Power costume is missing outline pixels, which is visible when playing The Forgotten. pic
Pits in the Flooded Caves don't match the floor color.
Gold and Red Chests, when acting as item pedestals, lack their black outline
Harlequin Baby's idle floating animation doesn't loop
Battery Baby/Lil Chest and similar familiars lack a bobbing up-and-down idle animations. Even the key pieces bob up and down, so they should too.
When you have an item that grants wings (Such as Fate or Lord of the Pit), and obtain the Guppy transformation afterwards (in that order), the wings will only show when the body is facing up, and is invisible in all other cardinal directions.
Pride's body does not change color in its walking animation when Pride is inflicted with a status effect.
Hush Flies in the bestiary use the black fly sprite/animation instead of their own sprite
Fred enemies spawned by the Mr. Fred boss (And potentially other bosses that spawn burrowing enemies) don't check to see what dirt color the room has, so it's always Womb red.
The Era Walk unlock banner has two stray pixels on it
Graphical oddity: Normal/Stone/Spiked/etc. Chests when opened in The Chest or Dark Room immediately change their item pedestal graphic to a Golden or Red Chest respectively depending on the floor no matter the original chest type. Similar happens with Slot Machine entities where they could use their broken graphic as an item pedestal, but instead use a generic item pedestal.
Trisagion shots look graphically odd when fired with Haemolacria, with the blood particles arching above the shot.
Same with Trisagion + Flat Stone, where the beams rapidly grow and dissipate
Saving and quitting while Mega Blast is active causes the player to have a stuck M. Blast firing animation
Bloody Lust is misnamed as 'Blood Lust' on Samson's character select.
Lilith's character select does not mention her starting with Box of Friends. This may be to reduce clutter, though Eve is able to have all 3 of her items listed.
Same could also be said about Lazarus' pill and Azazel's card, seeing how it now mentions that Maggy starts with a pill.
The Steam achievement icon for Missing No. has a Challenge Reward background color instead of the Boss Rush color. It could hold true for the glitch theme of the item, but Undefined is also unlocked via Boss Rush and that achievement icon has the proper green background color.
The Suicide King achievement has a Boss Rush color instead of a Challenge run color. There may have been a swap between Missing No. and Suicide King unlocks somewhere during development.
Bone Baby's Steam achievement background color is golden, which doesn't match with the other co-op babies also unlocked by clearing the hard mode post-it note 100%. Though this is also the background color for Godhead, so alternatively all the hard-mode completion unlocks could be gold to all match.
The Locust of War Steam achievement is still incorrectly named Wrath even though the name was changed.
Various achievements are using their old sprites, like Karma and Abaddon. This is extremely minor however, and previous versions still use the older sprites
The 7 Seals secret unlock icon borrowed from console versions features the old sprite design for the item instead of the new one. If anyone in the community is willing to make up a new unlock sprite for it I'll throw it into the post right here.
Mega Satan's boss room has some particularly messy floor graphics, with the crumbling floor sprite being visibly cut off, to the pits at the top of the room being visible in a messy way. This Workshop mod fixes up these graphics to help make it look a lot more clean (It also fixes up the pit graphics for Dark Room, which can look particularly odd when boss rooms in The Void use the Dark Room tileset).
This post had reached the Reddit character limit, so you can find the Rooms section on Pastebin here: https://pastebin.com/HaKUbxbi
This post had reached the Reddit character limit, so you can find the Sounds section on Pastebin here: https://pastebin.com/yxENS9Lz
This post had reached the Reddit character limit, so you can find the Miscellaneous section on Pastebin here: https://pastebin.com/sesPFCh8
This post had reached the Reddit character limit, so you can find the Delirium & Delirious section on Pastebin here: https://pastebin.com/fXudA0bv
On dailies/challenges if your objective is to reach Mega Satan you start the run with both Key Pieces. If you open the Mega Satan door (getting rid of your Key) and use Forget-Me-Now afterwards, you're granted both Key Pieces again. However, if you instead go through a trapdoor (e.g. through a Normal Button in a Secret Room) the Key Pieces do not respawn again.
In general, I Am Error rooms are disabled on the last floors of challenges/daily runs. However, if the final destination floor ends up being an XL floor (Depths, Womb), the I Am Error room will still spawn, allowing unintended skipping of the destination.
Queen Of Pentacles
EDIT: Linux supposedly got a large batch of fixes/missing features in the patch notes. I need Linux players to help report if there are any remaining issues, or if Linux is matched with the PC version now.
In Daily or seeded runs, the seed appears to be different/inconsistent on Linux with other OS's. I am unsure if different OS's use different Daily scoreboards, but this comment chain has a small report of this potential seed inconsistency.
The playback of most of the endings are incorrectly sped up. Most of the Epilogue, and endings 17 through Finale all play fine. However, the end of the Epilogue (The part where Isaac's mother opens the door) plays back at hyper speed, and Endings 1 through 16 all play back at a slightly faster speed (Most noticeable in endings 13, 14, 15).
Sometimes sound effects appear to be dropped and fail to play. It doesn't appear to be that consistent or easily replicable.
YO LISTEN!'s glow effect is incorrectly offset from the sprite itself
If you die with Guppy's Collar, exit and reenter the software, then continue the run, you'll die again as expected but the Guppy's Collar revive chance is rolled again, allowing you to exploit the item.
Queen Of Cups
There's the list so far. Let me know if I'm missing anything, or you have your own bugs/oddities I'm not aware of that you'd like to share so I can add to the list.
P.S. you're doing god's work Kil, keep it up 👍